H2O2-induced Ca overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway
نویسندگان
چکیده
EMILY C. ROTHSTEIN,1 KENNETH L. BYRON,2 RYAN E. REED,1 LARRY FLIEGEL,3 AND PAMELA A. LUCCHESI1 1Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; 2Department of Medicine and the Cardiovascular Institute, Loyola University Chicago, Maywood, Illinois 60153; and Department of Biochemistry, University of Alberta Edmonton, Edmonton, Alberta, Canada T6G 2H7
منابع مشابه
H(2)O(2)-induced Ca(2+) overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway.
Generation of reactive oxygen species (ROS) and intracellular Ca(2+) overload are key mechanisms involved in ischemia-reperfusion (I/R)-induced myocardial injury. The relationship between I/R injury and Ca(2+) overload has not been fully characterized. The increase in Na(+)/H(+) exchanger (NHE-1) activity observed during I/R injury is an attractive candidate to link increased ROS production wit...
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